Irreverent comedian and social commentator David Cross works consistently in TV, film, and the live performance circuit, endearing him to legions of fans. His smart and fearless comedy style is marked by a simultaneous honesty and cynicism that kind of goes beyond satire to somewhere else. His solo work tends to focus on topics of religion, politics, and a total refusal to skirt around any issue.

David Cross had a strong supporting part in the beloved comedy Arrested Development.

Characterized by his small frame, bald head, and black glasses, his major career accomplishment has been as one-half of the HBO series Mr. Show with Bob and David. However, his memorable bit parts (Donnie, the guy who repeatedly says "Chicken Pot Pie" on NBC's Just Shoot Me) tend to stick in the imagination of the larger public.

Cross met Bob Odenkirk while working as a writer for The Ben Stiller Show on HBO and the two joined forces to create the unique sketch comedy series Mr. Show in 1995. With Odenkirk and Cross as the original funders, writers, actors, and executive producers, the show was nominated for several Emmy awards and eventually ended in 1998. During this time, Cross made several notable TV guest appearances on The Drew Carey Show, News Radio, and a couple of Cartoon Network shows. After making his film debut with a short bit in Destiny Turns on the Radio, his big-screen career continued in this pattern with funny yet really small roles in The Truth About Cats & Dogs, Men in Black, The Cable Guy, and Waiting for Guffman. The small film roles continued in Ghost World, Pootie Tang, Scary Movie 2, and both Men in Black movies.

In November 2002, Cross released a two-disc comedy album, ‘Shut up You F***ing Baby!’, consisting of highly charged political rants and other solo material recorded live in concert. In 2003, he appeared in Melvin Goes to Dinner, written by Odenkirk, as well as Eternal Sunshine of the Spotless Mind, written by Charlie Kaufman.